Volume: 16, Issue: 2(2006)
pp. 79-97 DOI: 10.1142/S0129065706000524
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| Title: |
BIOPHYSICAL AND PHENOMENOLOGICAL MODELS OF MULTIPLE SPIKE INTERACTIONS IN SPIKE-TIMING DEPENDENT PLASTICITY |
| Author(s): |
MATHILDE BADOUAL
Integrative and Computational Neuroscience Unit (UNIC), CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, FranceQUAN ZOU
Integrative and Computational Neuroscience Unit (UNIC), CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, FranceANDREW P. DAVISON
Integrative and Computational Neuroscience Unit (UNIC), CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, FranceMICHAEL RUDOLPH
Integrative and Computational Neuroscience Unit (UNIC), CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, FranceTHIERRY BAL
Integrative and Computational Neuroscience Unit (UNIC), CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, FranceYVES FRÉGNAC
Integrative and Computational Neuroscience Unit (UNIC), CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, FranceALAIN DESTEXHE
Integrative and Computational Neuroscience Unit (UNIC), CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France
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| Abstract: |
Spike-timing dependent plasticity (STDP) is a form of associative synaptic modification which depends on the respective timing of pre- and post-synaptic spikes. The biophysical mechanisms underlying this form of plasticity are currently not known. We present here a biophysical model which captures the characteristics of STDP, such as its frequency dependency, and the effects of spike pair or spike triplet interactions. We also make links with other well-known plasticity rules. A simplified phenomenological model is also derived, which should be useful for fast numerical simulation and analytical investigation of the impact of STDP at the network level. |
| Keywords: |
Computational models; STDP; LTP; LTD; synaptic plasticity; calcium; kinetics; enzymes
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